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This groundbreaking Cell publication is the first to establish CD36 as a key endocytic receptor for bRo5-class drugs and to propose a generalized "CD36-mediated chemical endocytosis" strategy

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SURMOUNT-3 For the SURMOUNT-3 trial, patients who lost at least 5% of their body weight after a 12-week intensive lifestyle intervention lead-in period that included a low-calorie diet, exercise and weekly counseling sessions, were randomly assigned to receive either tirzepatide or placebo for 72 weeks to assess the efficacy and safety of the drug